Content based image retrieval for bio-medical images

Content Based Image Retrieval System (CBIR) is used to retrieve images similar to the query image. These systems have a wide range of applications in various fields. Medical subject headings, key words, and bibliographic references can be augmented with the images present within the articles to help clinicians to potentially improve the relevance of articles found in the querying process. In this research, image feature analysis and classification techniques are explored to differentiate images found in biomedical articles which have been categorized based on modality and utility. Examples of features examined in this research include: features based on different histograms of the image, texture features, fractal dimensions etc. Classification algorithms used for categorization were 1) Mean shift clustering 2) Radial basis clustering. Different combinations of features were selected for classification purposes and it was observed that features incorporating soft decision based HSV histogram features give the best results. A library of features was then developed which can be used in RapidMiner. Experimental results for various combinations of features have also been included --Abstract, page iii

Tumor-induced osteomalacia: experience from three tertiary care centers in India

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by recalcitrant hypophosphatemia. Reports from the Indian subcontinent are scarce, with most being single center experiences involving few patients. Herein, we conducted a retrospective analysis of 30 patients of TIO diagnosed at three tertiary care hospitals in India. Patients with persistent hypophosphatemia (despite correction of hypovitaminosis D), normocalcemia, elevated alkaline phosphatase, low TmP/GFR and elevated or ‘inappropriately normal’ FGF23 levels were labeled as having TIO. They were sequentially subjected to functional followed by anatomical imaging. Patients with a well-localized tumor underwent excision; others were put on phosphorous and calcitriol supplementation. The mean age at presentation was 39.6 years with female:male ratio of 3:2. Bone pain (83.3%) and proximal myopathy (70%) were the chief complaints; 40% of cases had fractures. The mean delay in diagnosis was 3.8 years. Tumors were clinically detectable in four patients (13.3%). The mean serum phosphate was 0.50 mmol/L with a median serum FGF23 level of 518 RU/mL. Somatostatin receptor-based scintigraphy was found to be superior to FDG-PET in tumor localization. Lower extremities were the most common site of the tumor (72%). Tumor size was positively correlated with serum FGF23 levels. Twenty-two patients underwent tumor resection and 16 of them had phosphaturic mesenchymal tumors. Surgical excision led to cure in 72.7% of patients whereas disease persistence and disease recurrence were seen in 18.2% and 9.1% of cases, respectively. At the last follow-up, serum phosphate in the surgically treated group was significantly higher than in the medically managed group

A Strategy for Noise Reduction to Improve Patient Experiences with Sleep (SNORES)

Aim Our aim was to improve patient-reported sleep satisfaction on the 5 W telemetry unit at Thomas Jefferson University Hospital over a 4 month time period (11/2018 to 2/2019) using a Marpac white noise machine.https://jdc.jefferson.edu/patientsafetyposters/1119/thumbnail.jp